‘Cowboy’ Donald Cerrone (28-6) and UFC lightweight champion Rafael Dos Anjos (24-7) will collide at the Amway Center in Orlando, Florida, December 19.
The two 155-pound stars first met in August of 2013, dos Anjos winning a three-round unanimous decision.
Since that fight, Cowboy has rattled off eight-consecutive win over notables such as Edson Barboza, Jim Miller, Benson Henderson, Eddie Alvarez and Myles Jury.
Dos Anjos claimed the UFC lightweight title in a unanimous decision win over former champion Anthony Pettis in March.
No other bouts have been announced for the UFC on FOX 17 event.